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ORIGINAL ARTICLE
Year : 2015  |  Volume : 16  |  Issue : 2  |  Page : 65-69

Comparison between trabeculectomy with Ologen implant and trabeculectomy alone in open-angle glaucoma


1 Ophthalmology Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt
2 Ophthalmology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Correspondence Address:
Hossam T Al-Sharkawy
Ophthalmology Center, Faculty of Medicine, Mansoura University, Elgomhoria Street, Mansoura 35516
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-9173.168532

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Purpose The aim of this study was to compare surgical outcomes of trabeculectomy with Ologen implant to trabeculectomy alone in terms of intraocular pressure (IOP), postoperative medications, bleb function, and postoperative complications in open-angle glaucoma. Patients and methods Setting : Mansoura Ophthalmic Centre and Al-Azhar University Hospital, Egypt. Design: Prospective study. Forty-two eyes of 30 patients with primary open-angle glaucoma (34 eyes, 80.95%) or pseudoexfoliation glaucoma (eight eyes, 19.05%) were included in this study. Twenty-one eyes were treated by subscleral trabeculectomy with a subconjuctival implant of Ologen over the closed scleral flap (Ologen or study group) and the other 21 eyes were treated by subscleral trabeculectomy alone (control group). One-year follow-up was completed for all eyes. Results Preoperatively, the mean IOP was 29.51 ± 2.85 mmHg in the Ologen group and 30.64 ± 2.36 mmHg in the control group. Postoperative mean IOP was13.26 ± 2.45 mmHg in the Ologen group and 16.85 ± 3.56 mmHg in the control group (P = 0.031). The mean number of postoperative antiglaucoma medications in the Ologen group was 0.43 ± 0.59 compared with 1.06 ± 0.85 drugs in the control group (P = 0.005). Conclusion The new degradable collagen implant (Ologen) improves and normalizes filtering surgical wound healing with more loosely organized and healthy bleb tissue and better IOP control than blebs formed with trabeculectomy alone in primary open-angle and pseudoexfoliation glaucomas.


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