• Users Online: 450
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2018  |  Volume : 19  |  Issue : 1  |  Page : 58-64

Evaluation of early versus late intravitreal bevacizumab injection in the treatment of macular edema secondary to branch retinal vein occlusion

Department of Ophthalmology, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Correspondence Address:
Hesham A Enany
Department of Ophthalmology, Faculty of Medicine, Zagazig University, Zagazig 44519
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/DJO.DJO_38_17

Rights and Permissions

Purpose The aim of this study was to evaluate the efficacy and safety of early versus late use of bevacizumab (Avastin) as an intravitreal injection in cases with branch retinal vein occlusion (BRVO). Patients and methods Twenty patients with BRVO with macular edema were divided according to the time elapsed between presentation and the onset of the vascular event into two groups: group I included 10 patients presenting within 3 months of BRVO and group II included 10 patients with BRVO presenting after 3 months of the vascular event. Patients in both groups received three intravitreal injections of bevacizumab. The first injection was administered at presentation, and then monthly for two additional doses. Results Foveal thickness measured by optical coherence tomography in µm decreased significantly after the intravitreal bevacizumab injection in group I from 451.5±57.9 to 428.1±59.5 after 1 month, to 369.5±52.6 after 3 months, and to 342.4±41.1 after 6 months, whereas in group II, the foveal thickness was reduced from 440.3±75.5 to 437.3±70.3 after 1 month, to 419.1±63.1 after 3 months, and to 380.1+69.4 after 6 months, a statistically insignificant difference. Best-corrected visual acuity in log MAR at baseline in group I was 0.84+0.2 and improved to 0.74+0.19 at 1 month, 0.74+0.25 at 3 months, and 0.72+0.15 after 6 months, whereas in group II, BCVA in log Mar at baseline was 0.75+0.2 and improved after 1 month of intravitreal bevacizumab injection to 0.74±0.26, to 0.74±0.27 after 3 months, and to 0.70±0.27 after 6 months. Conclusion The study showed improved visual acuity following treatment of BRVO-associated macular edema with bevacizumab intravitreal injections. The benefit was greater in the patients who received the first injection early in the course of the disease and in patients in whom three injections were administered.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded62    
    Comments [Add]    

Recommend this journal