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ORIGINAL ARTICLE
Year : 2019  |  Volume : 20  |  Issue : 3  |  Page : 132-137

Comparative study between patients with subclinical diabetic retinopathy and healthy individuals in the retinal microvascular changes using optical coherence tomography angiography


Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Correspondence Address:
MD Abd El-Magid M Tag El-Din
Flat 602, Building 13, Omar Zaafan Street, 1st District, Nasr City, Cairo 11765
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/DJO.DJO_8_19

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Purpose The aim of this study was to compare between patients with subclinical diabetic retinopathy (DR) and healthy individuals in the retinal microvascular changes including vascular density (VD), perfusion density (PD), and foveal avascular zone (FAZ) parameters by using optical coherence tomography angiography (OCTA). Patient and methods A total of 50 individuals were categorized into two groups: group A (healthy individuals) and group B (diabetic patients). Full ophthalmic examination, best-corrected visual acuity, intraocular pressure measurement, fundus fluorescein angiography, optical coherence tomography, and OCTA were done for all patients. Results Statistically significant differences were found between the healthy group and the diabetic group in OCTA parameters. VD and PD were significantly decreased in the diabetic patients (P>0.001). FAZ showed significant changes in area value and perimeter; however, the circularity changes were statistically insignificant. Conclusion OCTA is an effective tool that can provide a noninvasive method in the differentiation between subclinical DR and normal individuals. The FAZ metrics, VD, and PD in patients with subclinical DR showed a significant deviation from the parameters obtained from normal healthy individuals.


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