Year : 2019 | Volume
: 20 | Issue : 2 | Page : 82--87
Electrophysiological study of thyroid ocular disorders
Mona Abdel Kader1, Naglaa Abass2
1 Depertment ophthalmology, Mansoura Ophthalmic Center, Mansoura Medicine Hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt
2 Depertment ophthalmology, Mansoura Medicine Hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Purpose The aims of this study were to evaluate the visual evoked potential (VEP) changes in thyroid ocular disorders and to correlate between VEP latencies and thyroid hormones.
Patients and methods The study participants were divided into four groups. Group 1 comprised 50 patients (100 eyes) with subclinical hypothyroidism (29 patients had recent hypothyroidism without treatment, and 21 patients had controlled hypothyroidism with treatment). Group 2 comprised 35 patients (70 eyes) with overt hypothyroidism (20 patients had recent hypothyroidism without treatment, and 15 patients had controlled hypothyroidism with treatment). Group 3 comprised 35 patients (70 eyes) with hyperthyroidism (18 patients had recent hyperthyroidism without treatment, and 17 patients were under treatment). Group 4 comprised 70 patients (140 eyes) with normal thyroid functions as a control group. Flash and pattern VEP and thyroid hormone assay were performed for all patients.
Results There was an increase in the latencies of VEP without statistically significant change in amplitudes in thyroid disorders (groups 1, 2, and 3) compared with the normal control group (group 4). The increase in latencies in group 1 was statistically insignificant (P>0.1), while, in groups 2 and 3, it was statistically significant (P<0.005 and 0.001, respectively). In group 3, there was a positive correlation between latencies and tri-iodothyronine (T3) and thyroxine (T4). The increase in p100 was accompanied with an increase in T3 and T4.
Conclusion VEP can detect the early optic nerve defects in the absence of any neurological or ophthalmological symptoms in thyroid disorders.
Mona Abdel Kader
Ophthalmology Center, Faculty of Medicine, Mansoura University, 35516 Mansoura
|How to cite this article:|
Abdel Kader M, Abass N. Electrophysiological study of thyroid ocular disorders.Delta J Ophthalmol 2019;20:82-87
|How to cite this URL:|
Abdel Kader M, Abass N. Electrophysiological study of thyroid ocular disorders. Delta J Ophthalmol [serial online] 2019 [cited 2020 Apr 8 ];20:82-87
Available from: http://www.djo.eg.net/article.asp?issn=1110-9173;year=2019;volume=20;issue=2;spage=82;epage=87;aulast=Abdel;type=0