Year : 2019 | Volume
: 20 | Issue : 4 | Page : 161--165
Incidence of retinopathy in patients with chronic hepatitis C treated with dual and triple antiviral protocols
Mouaz A Abd-Elhadi1, Hazem E Haroun2, Noha M Khalil3, Safaa A Aboud2
1 Department of Ophthalmology, Ahmed Maher Teaching Hospital, Cairo, Egypt
2 Department of Ophthalmology, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt
3 Department of Ophthalmology, Faculty of Medicine, Cairo University, Giza, Egypt
Purpose The aim of this study was to compare the incidence of ophthalmological complications in chronic hepatitis C virus patients treated with dual versus triple antiviral protocols.
Study design A Prospective, observational, comparative study.
Setting Ahmed Maher Teaching Hospital and revised in the Outpatient Clinic of Ophthalmology Department of Beni Suef University.
Patients and methods One hundred and fifty chronic hepatitis C virus patients were treated by dual therapy of sofosbuvir and ribavirin for 6 months (group A), and 150 patients were treated by triple therapy of sofosbuvir, ribavirin, and interferon pegylated interferon (pegINF-α) for 3 months (group B). Full general and ophthalmological examinations were done at the baseline visit before receiving treatment and at 3 and 6 months after treatment. Any ophthalmological complications including deterioration in best corrected visual acuity, anterior segment inflammation, or retinal complications in the form of hemorrhages, soft exudates, or changes in cup/disk ratio were recorded.
Results In 11% of the patients under triple therapy, retinal hemorrhages and soft exudates were detected by the second visit; however, they resolved by the third visit. Patients under dual therapy showed no ophthalmological complications throughout the 6-month follow-up period. No uveitis or changes in best corrected visual acuity and cup/disk ratio were detected.
Conclusion Interferon-free protocols showed no retinal complications. However, the retinal complications related to the interferon-containing protocols resolved shortly within weeks. Thus, interferon-free protocols showed higher safety on the eye.
MD Noha M Khalil
10 Street Haroun, Dokki, Cairo 12311
|How to cite this article:|
Abd-Elhadi MA, Haroun HE, Khalil NM, Aboud SA. Incidence of retinopathy in patients with chronic hepatitis C treated with dual and triple antiviral protocols.Delta J Ophthalmol 2019;20:161-165
|How to cite this URL:|
Abd-Elhadi MA, Haroun HE, Khalil NM, Aboud SA. Incidence of retinopathy in patients with chronic hepatitis C treated with dual and triple antiviral protocols. Delta J Ophthalmol [serial online] 2019 [cited 2020 Apr 8 ];20:161-165
Available from: http://www.djo.eg.net/article.asp?issn=1110-9173;year=2019;volume=20;issue=4;spage=161;epage=165;aulast=Abd-Elhadi;type=0